The low use of Android-based interactive learning media is the driving force behind this research. This study aims to determine the validity and applicability of Android-based interactive learning media in integrated theme learning in class V SD by utilizing iSpring Suite and Website 2 APK Builder. Development research (R&D) with the ADDIE paradigm is this type of research. The results of the media material validity test, media validity test, and language validity test all fall into the valid category with a combined percentage of 94.73%, 96.42%, and 87.5% respectively. The percentage of 87.5% for the teacher's response questionnaire and 94.04% was obtained from the results of the practicality test for the student's response questionnaire in the pilot school. The percentage of 87.5% for the teacher response questionnaire and 94.34% was obtained from the practicality test results for the student response questionnaire in research schools. Thus, the integration of theme learning in class V SD with interactive learning media based on Android using iSpring Suite and Website 2 APK Builder is valid and practical.