The article presents an analysis of the methods that can be used to assess the impact of large industrial monopolies on the ecological state of the region, their sizes and indicators. The analysis of the methods of determining the coefficient indices of large enterprises in ensuring the ecological safety of the region while achieving economic well-being, environmental impact and efficient use of natural resources, reflecting environmental criteria and environmental quality indicators in financial statements in standard market assessments, which evaluate the activities of the enterprise from the point of view of balanced ecological and economically sustainable development, is presented. Highlights: Impact Analysis: Assess industrial monopolies’ ecological effects and regional safety. Methods: Evaluate coefficient indices linking environmental impact with economic well-being. Sustainability: Balance ecological criteria in financial reports for sustainable development. Keywords: ecological state, assessment of the ecological state, environment, ecological safety, ecological impact in stabilizing the regional economy, environmental objects, ecological impact coefficient index