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All Journal Jurnal Sehat Indonesia (JUSINDO) Jurnal Sosial dan Sains
Mallo, Andly Resando
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Astronomy Dentistry Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Jurnal Sosial dan Sains

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Burn Contracture In Children : A Case Series Mallo, Andly Resando; J. Hatbie, Mendy; Oley, Maximillian Christian
Jurnal sosial dan sains Vol. 4 No. 7 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i7.1420

Abstract

Background: Contractures after burns are the most common complication, should be prevented, and if they occur, are more difficult to treat. In developing countries such as Indonesia, it is more difficult for children with burns to get treatment for acute burns, resulting in joint contractures and soft tissue weakness. On the other hand, if contractures have already appeared, various methods such as z-plasty, multiple s-plasty, and even reconstructive flaps can be performed, especially in persistent contractures. Purpose: This study aims to find out several types of therapy and surgical management that can be carried out in contracture patients. Method: This study uses a qualitative research method with a case study approach. The data collection techniques used in this study are observation, medical record study, and literature study. The data that has been collected is then analyzed through three stages, namely data reduction, data presentation, and conclusion drawing. Results: The results of the study show that early management of burns in children can provide a better prognosis, if contractures have occurred, treatment requires several stages and the function cannot return to normal and aesthetics can be improved according to the difficulty of the burn. contracture. Conclusion: Research on contractures due to burns in children shows that early management can provide a better prognosis. If contractures have formed, treatment requires several stages and often cannot completely restore normal function.
Respon Klinis Regimen Kemoterapi pada Kanker Payudara Stadium Lanjut di RSUP Prof. Dr. R. D. Kandou Manado Tahun 2023 Mallo, Andly Resando; Manginstar, Christian; A. Merung , Marselus; Langi, F.E.L. Fredrik G.O
Jurnal sosial dan sains Vol. 4 No. 10 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i10.20033

Abstract

Latar Belakang: Kanker payudara merupakan salah satu penyebab utama morbiditas dan mortalitas di kalangan wanita di seluruh dunia. Di Indonesia, distribusi subtipe kanker payudara dan respons terhadap pengobatan bervariasi. Penelitian ini bertujuan untuk mengevaluasi respon klinis terhadap berbagai regimen kemoterapi pada pasien kanker payudara stadium lanjut di RSUP Prof. Dr. R. D. Kandou Manado tahun 2023. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi respon klinis terhadap regimen kemoterapi pada kanker payudara stadium lanjut serta menganalisis hubungan antara subtipe molekuler dengan respon klinis terhadap kemoterapi. Metode: Penelitian ini menggunakan desain studi observasional retrospektif dengan pendekatan potong lintang. Data dikumpulkan dari rekam medis pasien kanker payudara stadium lanjut yang menjalani kemoterapi di RSUP Prof. Dr. R. D. Kandou pada tahun 2023. Respon klinis dievaluasi menggunakan kriteria RECIST, dengan variabel bebas berupa regimen kemoterapi dan variabel tergantung berupa respon klinis. Hasil: Dari 190 pasien, 45,3% menunjukkan Partial Response (PR), 30,5% Stable Disease (SD), dan 4,2% mengalami Progressive Disease (PD). Regimen Platinum + Taxane (TP) merupakan regimen paling banyak digunakan dengan respon klinis yang signifikan. Subtipe Triple Negative memiliki prevalensi tertinggi di antara pasien, dengan respon klinis yang bervariasi. Kesimpulan: Hasil penelitian menunjukkan bahwa mayoritas pasien kanker payudara stadium lanjut di RSUP Prof. Dr. R. D. Kandou merespon positif terhadap kemoterapi, dengan Partial Response sebagai respon terbanyak. Regimen TP menunjukkan efektivitas tinggi dalam meningkatkan respons klinis pada subtipe kanker payudara Triple Negative.
Co-Authors A. Merung , Marselus J. Hatbie, Mendy Langi, F.E.L. Fredrik G.O Manginstar, Christian Mendy Hatibie Oley, Maximillian Christian