This study describes a case of Ischialgia caused by hernia nucleus pulposus (HNP) in a 44-year-old male patient. The patient presented with complaints of pain in the buttocks radiating to the right leg, accompanied by tingling and numbness, particularly after heavy physical activity. The diagnosis was established through anamnesis, physical examinations such as the Lasegue, Bragard and Socard tests, and MRI imaging, which revealed bulging discs at L1-2, L2-3, L3-4, L4-5, and L5-S1. Management was conducted using a holistic approach, including pharmacological therapy (NSAIDs, muscle relaxants, and vitamin B12), physiotherapy, and a lumbar corset to support spinal stability. After four days of treatment, the patient showed significant improvement, with the Visual Analog Scale (VAS) pain score decreasing from 8 to 3, normal motor strength recovery, and improved walking ability. Lifestyle modification education was provided to prevent recurrence, such as reducing heavy physical activities and engaging in controlled physical exercises. These results emphasize the importance of early diagnosis and multidisciplinary therapy in managing HNP cases to enhance the patient’s quality of life. This case contributes significantly to clinical practice by demonstrating the effectiveness of an integrated approach in optimally managing HNP.