Purpose -This study aims to explore the application of Pancasila values in the context of the development of science and technology in Indonesia. The main focus is how Pancasila can be a philosophical foundation as well as an ethical guideline in directing innovation and technological progress in accordance with the character of the nation.Research Methodology / Design / Approach -The method used in this study is a literature review. This approach involves analyzing various sources that discuss the relationship between Pancasila values and the development of science and technology in Indonesia.Findings The results of the analysis show that Pancasila not only functions as a philosophical basis but also as an ethical guide in innovation and technological development. Values such as social justice, unity, and just and civilized humanity are important criteria in determining the direction and impact of technological development.Originality / Value- This study emphasizes the importance of integrating Pancasila values at every stage of the development of science and technology in order to align with the needs of society and the character of the Indonesian nation. These findings provide a strategic contribution for policy makers and innovators to prioritize moral and social aspects in technological progress.