This study aims to examine and analyze the influence of organizational culture, leadership, and work stress on employee performance within the Maluku Province Information and Communication Service. The research follows a survey methodology, employing a quantitative analysis approach for data analysis. The study utilizes a census sampling technique, involving a total of 97 respondents. The data is subjected to multiple linear regression for statistical analysis. The results of the quantitative analysis establish several key findings. Organizational culture exhibits a significant positive impact on enhancing employee performance, while leadership also significantly contributes to improved employee performance. On the other hand, work stress demonstrates a notable negative influence on employee performance. For future researchers, it is recommended to consider incorporating additional variables, such as role ambiguity, and applying Structural Equation Modeling (SEM) analysis for a more comprehensive understanding of the relationships.