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Astriani Natalia Br Ginting
Universitas Prima Medan
Education Languange, Linguistic, Communication & Media Mathematics Social Sciences Other

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Journal : Journal of Innovative and Creativity

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Efektivitas Gel Ekstrak Etanol Daun Bakung (Crinum Asiaticum L.) Terhadap Luka Pada Model Tikus Diabetes Inggried Audrey; Astriani Natalia Br Ginting; Finna Piska
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.6035

Abstract

Diabetes is a metabolic disease caused by hyperglycemia, often accompanied by chronic skin lesions. Wounds occur due to infections that appear on the skin. Daffodils have been used by the community as medicine, which is usually used to heal bruises, low back pain, fractures, and antidiabetics. Daffodils contain secondary metabolites such as alkaloids, flavonoids, saponins and terpenoids. Each compound has a specific mechanism in the healing of diabetic wounds. This study aims to determine the effect of giving daffodil ethanol extract gel in the healing of wounds in male rat models of diabetes. This research method in vivo used induced male rats with an allexone of 120mg/kgBB. The treatment in rats was divided into 6 treatments, namely normal, negative control, positive control, GEDB 5%, GEDB 10%, GEDB 15%. This study was carried out for 14 days with gel application twice a day. The results of the study showed that 5% Lily Leaf Extract Gel showed complete wound healing in rats. The concentrations of GEDB of 5% and 10% turned out to be almost as effective as chloramphenicol cream, where the wound was completely closed on the 14th day and the healing rate was quite high. The conclusion obtained is that Lily Leaf Extract Gel can treat diabetic wounds in rats.
Efektivitas Ekstrak Etanol Buah Bit (Beta Vulgaris L.) Terhadap Penurunan Glukosa Darah Pada Tikus Model Diabetes Otniel Agung Ahasyweroz T; Astriani Natalia Br Ginting; Vera Estefania Kaban
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.6036

Abstract

Diabetes is a metabolic disease caused by hyperglycemia, characterized by an increase in blood sugar levels because insulin does not function properly. Beetroot is rich in fiber, minerals such as potassium, sodium, vitamins, and iron which are very beneficial for the body. In addition, this fruit also has bioactives such as betalain, phenolics, and saponins This study aims to determine the effect of giving lily ethanol extract gel in healing wounds in male rat diabetic models. This research method in vivo used induced male rats with an allexone of 120mg/kgBB. Treatment in rats was divided into 6 treatments, namely normal, negative control, positive control EEBB 200mg/KgBB, EEBB 400mg/KgBB, EEBB 600mg/KgBB. This study was conducted for 15 days. The results showed that Beet Ethanol Extract at a dose of 600mg/Kg BB showed the most significant decrease in blood glucose in rats. Doses of 200 and 400 turned out to be almost as effective as metformin tablets. The conclusion obtained is that Beet Fruit Ethanol Extract (Beta vulgaris L.) is effective in lowering blood glucose levels.
Co-Authors Finna Piska Inggried Audrey Otniel Agung Ahasyweroz T Vera Estefania Kaban