PERAN POLIMORFISME GEN METHYLENTETRAHYDROFOLATE REDUCTASE MTHFR PADA CEREBRAL PALSY

Uni Gamayani . Ponpon Idjradinata, M. Hasan Machfoed, Tri Hanggono Achmad

Majalah Kedokteran Neurosains
Vol 32 No. 2 Maret 2015

INTRODUCTION CEREBRAL PALSY CP IS THE MOST COMMON NEURODEVELOPMENTAL DISORDER IN CHILDREN THE RISK FACTORS OF CP ARE OFTEN FOUND DURING PRENATAL PERIOD GENETIC FACTORS ARE CONSIDERED TO BE A RISK FACTOR CONTRIBUTING TO THE PATHOGENESIS OF BRAIN INJURY IN CP GENETIC RISK FACTOR IS IMPORTANT BECAUSE THERE IS AN INTERACTION BETWEEN ENDOGENOUS AND EXOGENOUS FACTORS WHICH CAN BE MANAGED TO IMPROVE THE QUALITY OF LIFE OF CP CHILDREN IMPLICATIONS OF GENETIC FACTOR LIKE METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR GENE POLYMORPHISM TO CP PATHOGENESIS AND PROGNOSIS ARE DISCUSSED