Biomolecular and Health Science Journal
Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal

The Role of JAK2 in Myeloproliferative Diseases Diagnosis

Yudith Annisa Ayu Rezkitha (Universtas Airlangga)
S. Ugroseno Yudho Bintoro (Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia)
Ami Ashariati (Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia)

Article Info

Publish Date
26 Nov 2018

Abstract

Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2.

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Journal Info
Biomolecular and Health Science Journal
Website

Abbrev

BHSJ

Publisher

Universitas Airlangga

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Description

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case ...