Placental Growth Factor Level is Lower in Early-Onset Preeclampsia, while Tumor Necrosis Factor Alpha Level does not Show any Difference between Early and Late Onset Preeclampsia

Christofani Ekapatria (Department of Obstetrics and Gynecology Faculty of Medicine University of Padjadjaran/ Dr. Hasan Sadikin Hospital Bandung)

Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Volume. 36, No. 4, October 2012

Objective: To analyze the difference of PlGF and TNF-α serum level between early-onset and late-onset preeclampsia. Method: This is a cross-sectional analytic comparative study comparing serum level of PlGF and TNF-α between groups with earlyand late-onset preeclampsia. Each group consists of 32 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital or its district hospitals in September - November 2012. Statistical analysis was performed with Kolmogorov Smirnov test, Saphiro-Wilk test, and non-parametric Mann-Whitney test. Result: Mean of PlGF serum level in the group with early-onset preeclampsia is 53.0344±38.07140 pg/ml, while mean of which in the group with late-onset preeclampsia is 241.8063±192.8373 pg/ml (p<0.0001). Mean of TNF-α serum level in the group with early-onset preeclampsia is 2.7733±0.97533pg/ml, while mean of which in the group with late-onset preeclampsia is 2.5061±0.84872 pg/ml (p= 0.235). Conclusion: Serum level of PlGF in early-onset preeclampsia is lower than the level of which in late-onset preeclampsia (p<0.0001). There is no significant difference of TNF-α serum level between the early- and late-onset preeclampsia (p=0.235). [Indones J Obstet Gynecol 2012; 36-4: 181-4] Keywords: early onset, late onset preeclampsia, PlGF, preeclampsia, TNF-α