Jurnal Kimia (Journal of Chemistry)
Vol. 3, No. 2 Juli 2009

PENELUSURAN SENYAWA SITOTOKSIK PADA KULIT BIJI NYAMPLUNG (Calophyllum inophyllum L.) DAN KEMUNGKINAN KORELASINYA SEBAGAI ANTIKANKER

Sri Rahayu Santi (Unknown)



Article Info

Publish Date
13 Nov 2012

Abstract

Isolation and identification of active toxic compounds from nyamplung skin bean (Calophyllum inophyllumL). has been carried out. As much as 12,43 g of concentrated methanol extract was resulted from 1.0 kg dry powdernyamplung skin bean that was macerated using methanol. This extract was dissolved into methanol-water (7:3) andthen partitioned with n-hexane and chloroform respectively. The result of toxicity test to both extract showed thatchloroform extract was the most active toxic with LC50 = 239,88 ppmSeparation of chloroform extract using preparative thin layer chromatography (TLC) resulted in F5 fractionsthat was white yellowish as much as 52 mg and LC50 = 151,36 ppm. Infra red and UV-vis spectroscopy wereemployed in order to identify the F5 fraction. The result of identification showed that isolate was aldehidetriterpenoide compounds which had functional group like –OH (3429 cm-1), -CH aldehyde (2922,9 and 2852,9 cm-1),-CºC- (2360 cm-1), -C=O (1742,7 cm-1), -C=C- alkene(1637,0 cm-1), -CH3, -CH2 (1542,9, 1480,7, 1401,9 cm-1), -CO-(1090 cm-1), It showed absorbed at broad peaks at l(nm) (CHCl3): 254, 282, and 342,7.

Copyrights © 2009






Journal Info

Abbrev

jchem

Publisher

Subject

Chemistry

Description

Jurnal Kimia (Journal of Chemistry) publishes papers on all aspects of fundamental and applied chemistry. The journal is naturally broad in scope, welcomes submissions from across a range of disciplines, and reports both theoretical and experimental ...