HIV is a virus that weakens the immune system. HIV can be classified into two genotypes, namely HIV-1 and HIV-2. Genotyping ofHIV-1 can be classified into three groups: group M, N, and O. Therapy for patients with positive HIV today is HAART or Highly ActiveAntiretroviral Therapy at present has much-experienced resistance to first-line. This study is an observational study with a crosssectionalstudy to determine the prevalence of resistance to first-line ARV therapy. The research was conducted from September2014 until January 2016 at the HIV clinic Sanglah Hospital. The data collection is done with a short interview and filling thequestionnaire, as well as secondary data from medical records of patients. Of the 68 samples that follow this study, 9 (13.2%) ofwhom experienced resistance and undergoing treatment with second-line antiretroviral drugs.
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