E-Jurnal Medika Udayana
vol 2 no4 (2013):e-jurnal medika udayana

FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

Ni Komang Tristiana Dewi (Unknown)
I Wyn. Sugiritama (Unknown)



Article Info

Publish Date
08 Apr 2013

Abstract

Androgenetic alopecia (AGA) is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT), which can lead to miniaturization of the hair follicle. Finasteride is one of drugs that proven effective in treating hair loss caused by AGA. Finasteride is a 4-azasteroid components that are competitive and specific inhibitor of the enzyme 5-?-reductase type II, an enzyme that converts testosteron into intracellular DHT. By inhibiting the enzyme 5-?-reductase type II, conversion of testosteron to DHT inhibited, thereby causing a significant decrease in serum and tissue DHT concentrations. The use of finasteride 1 mg per day proven to effectively treat AGA in men.  

Copyrights © 2013






Journal Info

Abbrev

eum

Publisher

Subject

Health Professions Medicine & Pharmacology

Description

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