Atom Indonesia Journal
Vol 38, No 1 (2012): April 2012

Study of 99mTc Pertechnetate Radiopharmaceuticals in Relation to Thyroid Hormone for Toxic and non-Toxic Diffuse Goiter

N.P. Viantri (Department of Physics, Mathematics and Natural Science, Diponegoro University, Semarang, Indonesia)
W. Setiabudi (Department of Physics, Mathematics and Natural Science, Diponegoro University, Semarang, Indonesia)
C. Anam (Department of Physics, Mathematics and Natural Science, Diponegoro University, Semarang, Indonesia)
F. Nadzir (Division of Nuclear Medicine, Pertamina Hospital Center (RSPP), Jakarta, Indonesia)
C. Varuna (Division of Nuclear Medicine, Pertamina Hospital Center (RSPP), Jakarta, Indonesia)



Article Info

Publish Date
26 Sep 2012

Abstract

Abnormalities of the thyroid gland in the form of enlargement of the thyroid gland are called a goiter. Goiter is divided into two types, namely toxic and non-toxic diffuse goiter. Diagnosis could be done with thyroid scan (in vivo) and test for thyroid hormone value (in vitro). Thyroid scan is applied by giving injection of 99mTc Pertechnetate as much as 2 - 5 mCi intravenally in the arm and then thyroid gland and salivary glands imaging were conducted in the fifth minute, tenth minute and fifteenth minute using gamma camera. Thyroid hormones test in blood is done with radioimmunoassay method. The same pattern showed the accumulation polad of the radioactive number from quotation of salivary glands. The accumulation percentage activity of 99mTc Pertechnetate in thyroid gland for the case of toxic diffuse goiter is larger than the case of non-toxic diffuse goiter. The results of this study indicate that the predictors for the case of toxic diffuse goiter could be characterized by high thyroid uptake which the the value of T3 hormone ≥ 3.3 ng/dl, the value of T4 hormone ≥ 165 nmol/l, and the value of TSH hormone ≤ 0.2 μIU/ml. While the case of non-toxic diffuse goiter could be characterized by low thyroid uptake which the value of T3 hormone ≥ 1.2 ng/dl, the value of T4 hormone ≥ 90 nmol/l, and the value of TSH hormone ≤ 1.8 μIU/ml. Received: 14 November 2011; Revised: 18 April 2012; Accepted: 21 April 2012

Copyrights © 2012






Journal Info

Abbrev

aij

Publisher

Subject

Materials Science & Nanotechnology

Description

Exist for publishing the results of research and development in nuclear science and technology Starting for 2010 Atom Indonesia published three times a year in April, August, and December The scope of this journal covers experimental and analytical research in all areas of nuclear science and ...