(Peer Review, Jurnal Ilmiah) Role of Soluble Heat Shock Proteins 70 in Severity of Dengue Infection

Dr. dr. Nurfadly, MKT. (Universitas Muhammadiyah Sumatera Utara)

KUMPULAN JURNAL DOSEN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
Vol 2, No 6 (2017): Role of Soluble Heat Shock Proteins 70 in Severity of Dengue Infection

Objective: to prove the role of soluble HSP 70 in the severity of dengue infection by comparing the level of solubI<fiSP 70 in patients who diagnosed as dengue fever (OF), deng!:]e hemon-ha ic fever (DJ- and I healthy people. Methods: Thi was a pro pective and longitudinal study, samples were taken by using consecutive sampling with a sample size were 22 OF patients, 20 DHF patients and 20 healthy people as a control group. Soluble HSP 70 in sertUn was measured by an enzyme-linked inununosorbent assay (ELISA). Results: The soluble I-ISP 70 was significantly increased (p=0.003) in DHF patients (0.33 ± 0.17 ng/ml) compared to in OF patients (0.149 ± 0.19 ng/ml) and control group (0.147 ± 0.37 ng/mJ), but there was not significantly increased (p=0.241) in OF patients compare within control group. Cone ion: This result suggesting that oluble HSP 70 may play important roles in the severity of dengue infection.