Circulating Immune Complex in Glomerular Diseases

H. Alatas (Department of Child Health, University of Indonesia, Jakarta)
I. G. N. Wila Wirya (Department of Child Health, University of Indonesia, Jakarta)
Taralan Tambunan (Department of Child Health, University of Indonesia, Jakarta)
S. Cornain (Department of Pathology, University of Indonesia, Jakarta)
Sucahyo Sucahyo (Department of Pathology, University of Indonesia, Jakarta)
S. Himawan (Department of Pathology, University of Indonesia, Jakarta)
Gunardjono Gunardjono (Department of Pathology, University of Indonesia, Jakarta)

Paediatrica Indonesiana
Vol 22 No 11-12 (1982): November - December 1982

Circulating Immune Complex (CIC) in the serum have been studied in 75patients with glomerular diseases. The highest positive rate in patients with post streptococcal glomerulonephritis and lupus nephritis were respectively 83.3% atld 75%.In nephrotic syndrome: 33.3% (5 jl5) was positive in diffuse mesangial proliferative cases, and in all 3 patient~· with membranoproliferative glomerulonephritis, membranous nephropathy and focal  glomerulosclerosis. All of them had detectable immune deposits in the glomeruli.In minimal lesion nephrotic syndrome (MLNS) without glomerular immunedeposits, CIC was positive in 2 out of 17 cases (12%). This support the hypothesis that in MLNS a humoral immune mechanil'im might take part in the pathogenesis of the disease.