Paediatrica Indonesiana
Vol 24 No 7-8 (1984): July - August 1984

The toxic effect of rhodamine B in rats

G. Nainggolan Sihombing (Nutrition Unit, Diponegoro National Institute for Health Research and Development, Ministry of Health, Jakarta)



Article Info

Publish Date
03 Aug 2018

Abstract

A multigeneration rat feeding study was carried out with rhodamine B incorporated in the usual stockdiet [or albino rats. Rhodamine B is a red inedible synthetic dyestuff wrongly but widely used in Jakarta for colouring cheap snacks and drinks prepared at the homelevel and sold by streetvendors. Under the conditions of the experiment the main findings observed were : 1) retardation of growth, starting from birth to adulthood 2) decrease in reproductive ability as seen from continuing decrease of littersize with each following generation 3) behavioral changes of adult rats, such as itching, irritability, aggressiveness and cannibalism 4) increased susceptibility to infection (respiratory diseases) in adult rats resulting in decreased longevity 5) development of tumors in the lymphnodes. The purpose of this investigation is through reporting the findings to awake renewed interest on the part of the authority for the problem of provision of the so badly needed cheap but edible foodgrade colours for the less privileged members of the society.

Copyrights © 1984






Journal Info

Abbrev

paediatrica-indonesiana

Publisher

Subject

Health Professions Medicine & Pharmacology

Description

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of ...