A personification heuristic Genetic Algorithm is established for the placement of digital microfluidics-based biochips, in which, the personification heuristic algorithm is used to control the packing process, while the genetic algorithm is designed to be used in multi-objective placement results optimizing. As an example, the process of microfluidic module physical placement in multiplexed in-vitro diagnostics on human physiological fluids is simulated. The experiment results show that personification heuristic genetic algorithm can achieve better results in multi-objective optimization, compare to the parallel recombinative simulated annealing algorithm. DOI: http://dx.doi.org/10.11591/telkomnika.v11i6.2667
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