<![CDATA[The SIR model is one of the mathematical model which describes the characteristic of the spread of infectious disease in differential equation form by dividing the human populations into three groups. There are individual susceptible group, individual infective group, and individual recovered group. This model involves vaccination, quarantine, and immigration factors. Vaccination and quarantine must be given as much as it needs, so a control is required to minimize infection of disease and the number of individual infective with a minimum costs. In this research, optimal control of SIR model with vaccination, quarantine, and immigration factor is solved by using Pontryagin maximum principle and numerically simulated by using Runge-Kutta method. Numerical simulation results show optimal control of treatment, citizen of vaccination, immigrant of vaccination, and quarantine will accelerate the decline of infected number with the minimum cost, compared with the optimal control of SIR model without quarantine factor.]]>
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