The purpose of the study was to determine the effect of family support in drug adherence on the subject of Human Immunodeficiency Virus with low self-esteem in the PELNI hospital in Jakarta. The research method in this study is Pre Experimental with One Group Pre-Test-Post Test Design. The results showed that family support could have a positive impact on reducing mental disorders in PLWHA, such as anxiety, stress, depression, and low self-esteem. Conclusions, the results of subjects I and II who experience low self-esteem cause disruption of self-role, disability, helplessness, negative self-ideal, and negative self-esteem. Keywords: Family Support, Low Self-Esteem, Medication Adherence, Human Immunodeficiency Virus
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