The reasearch test effect anthypercholesterolemia Chytosan Windu Shrimp Shell with aimed to know the effect to decrease the total blood cholesterol degree on adult rabbit. These research include 3 group, namely 1 group of control and 2 groups of examined namely chytosan 5% and 10% w/v. The observation applied with measure of the total blood cholesterol degree on adult rabbit before induction of cholesterol, then inducted of cholesterol as long as 7 days, then observed cholesterol degree, and then its gived chytosan 400 mg/kgBB (5%w/v) and 800 mg/kgBB (10%w/v) at the 8th and measured again of the total blood cholesterol degree after examined Chytosan at concentration 400 mg/kgBB (5%w/v) dan 800 mg/kgBB (10%w/v), conduct decreasing of total blood cholesterol degree on adult rabbit. Key Word : Antihypercholestrolemia, Penaeus monodo, Oryctolagus cuniculus, Invivo
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