As-syifaa Jurnal Farmasi
Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi

STABILITAS DAN MASA SIMPAN SEDIAAN SUSPENSI KERING ERITROMISIN ETILSUKSINAT DENGAN VARIASI BAHAN PENSUSPENSI

Faradiba Faradiba (Fakultas farmasi Universitas Muslim Indonesia Makassar)
Amran Ilyas Tandjung (Fakultas Farmasi Universitas Hasanuddin Makassar)
Nur Fadillah (Fakultas farmasi Universitas Muslim Indonesia Makassar)



Article Info

Publish Date
01 Jul 2011

Abstract

An Investigation on how to know the chemist stability and the expired date on dry suspension formulation of erythromycin ethylsuccinate has been done in variation of suspending agents.Evaluation of Chemical stability has been done by inspection a rate of eritromisin degradation with accelerated stability test by stored sample on temperature above room temperature (250C) that is 30, 40, 50 and 600C during 4 days and decided the remain of the erythromicyn concentration each 1 day (24 hours).The Results is rate of erythromycin degradation in stored by normal temperature (250C) for the formula I, II and III to follow that is 0,00043 day-1; 0,00026 day-1 and 0,00064 day-1.  Th stored time for the formula I, II and III to follow that is 0,7; 1,13; and 0,5 years. The result have been shown that formula II (Gum xanthan as a suspending agent) was the most stable dry suspension chemically.Key Words : Stability , Expired Date,  Dry Suspension , Erythromycin Ethylsuccinate , Suspending Agent

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Journal Info

Abbrev

as-syifaa

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, ...