<![CDATA[Cardiovascular diseases (CVD) is among the major health ailment issue leading to millions of deaths every year. In recent past, analyzing gene expression data, particularly using machine learning strategies to predict and classify the given unlabeled gene expression record is a generous research issue. Concerning this, a substantial requirement is feature optimization, which is since the overall genes observed in human body are closely 25000 and among them 636 are cardio vascular related genes. Hence, it complexes the process of training the machine learning models using these entire cardio vascular gene features. This manuscript uses bidirectional pooled variance strategy of ANOVA standard to select optimal features. Along the side to surpass the constraint observed in traditional classifiers, which is unstable accuracy at k-fold cross validation, this manuscript proposed a classification strategy that build upon the swarm intelligence technique called cuckoo search. The experimental study indicating that the number of optimal features those selected by proposed model is substantially low that compared to the other contemporary model that selects features using forward feature selection and classifies using SVM classifier (FFS and SVM). The experimental study evinced that the proposed model, which selects feature by bidirectional pooled variance estimation and classifies using proposed classification strategy that build on cuckoo search (BPVE and CS) outperformed the selected contemporary model (FFS and SVM).]]>
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