ISOLATION, STRUCTURE ANALYSIS, AND ANTIBACTERIAL ACTIVITY OF BIFLAVONOID GB-1 FROM Garcinia tetranda Pierre

Novi Sulistyaningrum (Pusat Biomedis & Teknologi Dasar Kesehatan-Badan Litbangkes Kemenkes RI)
Taslim Ersam (Jurusan Kimia-Fakultas MIPA, ITS Surabaya)

Widyariset
Vol 15, No 3 (2012): Widyariset

Garcinia tetranda Pierre (Clusiaceae) was reported as source of flavonoid which has various bioactivities forhealth. Pure compound has been isolated by repeat chromatography techniques (Vacuum Column Chromatography,preparative TLC and TLC). UV, IR, 1H-NMR and 13C-NMR spectroscopic data of isolated compound (isolate)compared with the compound which was found before, and showed same as biflavonoid GB-1 data. Antibacterialassay against Salmonella typhi showed lower activity than chloramphenicol. Biflavonoid GB-1 compound foundin this study is different to the previous study, which all of compounds were classified as xanthones. Therefore,result of this study improves compound variability of Garcinia tetranda. However GB-1 is not potentially used asGram-negative antibacterial agent, especially against Salmonella typhi.