Jurnal Ilmiah Farmasi
Vol. 2 No. 2 (2005)

SINTESIS DIASETIL GAMAVUTON-0 DENGAN MENGGUNAKAN ASETIL KLORIDA SEBAGAI ACYLATING AGENT

Ridho Nugroho Zendrato (Unknown)
Supardjan Amir Margono (Unknown)

Article Info

Publish Date
17 Feb 2012

Abstract

ABSTRACTGamavuton-0 is a curcumin-like compound, which is more stable than curcumin and stillhas an antioxidant property. The objective of synthesis of diacetyl gamavuton-0 (diAcGVT-0) is toyield the product that is more lipophile than GVT-0. Synthesis of diAcGVT-0 has been done byreacting GVT-0 with acetyl chloride as an acylating agent and tertiary amines as primary bases.DiAcGVT-0 was formed as the major product of synthesis and the product was not pure. Structureelucidation using UV-Vis,1H-NMR and MS spectra showed that the main product was diAcGVT-0.Key words : diacetyl gamavuton-0, acetyl chloride, acylating agent, lipophile

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Journal Info
Jurnal Ilmiah Farmasi
Website

Abbrev

JIF

Publisher

Universitas Islam Indonesia

Subject

Medicine & Pharmacology

Description

JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta ...