Paediatrica Indonesiana
Vol 60 No 4 (2020): July 2020

Case report of Fanconi syndrome in Wilms tumor

Ayu Hutami Syarif (Department of General Medicine, Indonesia National Cancer Center - Dharmais Cancer Hospital)
Edward Usfie Harahap (Department of Urology, Indonesia National Cancer Center - Dharmais Cancer Hospital)
Mururul Aisyi (1. Department of Pediatric Hematology Oncology, Indonesia National Cancer Center - Dharmais Cancer Hospital)



Article Info

Publish Date
07 Jul 2020

Abstract

Fanconi syndrome is a group of clinical manifestations including aminoaciduria, proteinuria, glycosuria, hypophosphatemia, and metabolic acidosis. It may occur after exposure to certain drugs. The most common causes are antiepileptic, antiviral, antibiotic, and antineoplastic drugs.1 The two most common causes in the antineoplastic regimen are cisplatin and ifosfamide. Ifosfamide, a derivative of cyclophosphamide, has been used to treat pediatric solid tumors.2 Its high efficacy in numerous studies has led to its long-term administration for pediatric malignancies, including Wilms tumor. Along with other treatment modalities, ifosfamide considerably improved the survival rate (90%) of Wilms tumor while only a few cases resulted in Fanconi syndrome.1,3,4 Here we illustrate a case of presumed drug induced Fanconi syndrome in a Wilms tumor patient who previously achieved remission for 10 months.

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Journal Info

Abbrev

paediatrica-indonesiana

Publisher

Subject

Health Professions Medicine & Pharmacology

Description

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of ...