This research used the dosage of radio active 125I of 5 mci and 10 mci, and used 32 two-month-old male white mice. The white mice were divided into four groups randomly. This research applied Split-plot Design. After being treated based on the gruping time, the data were obtained, then analyzed with the following result . Group of 16 day t- test of the control erythrocyte ( c-1 ) and the erythrocyte after the break of the treatment of 5 mci of radio-active 125I dosage showed significant ( p< 0,05 )unreversible. Group of 32 days t- test of the control erythrocyte ( c-2 )and the erythrocyte after the break of the treatment of 10 mci of radio-active 125I dosage showed non significant difference (p>0,05) reversible
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