Production of Free Radicals by Mitochondria: A Biochemistry Approach

Usman Garba Kurmi (University of Maiduguri)
Fatima Abubakar (University of Maiduguri, Nigeria)
Ruqayya Ali Uthman (Bayero University Kano, Nigeria)
Isah Adamu Baushe (Yobe State University, Nigeria)
Hadiza Abubakar Balkore (University of Maiduguri, Nigeria)
Khadija Muhammad (Kaduna State University, Nigeria)
Prosper Obed Chukwuemeka (Federal University of Technology Akure, Nigeria)

International Journal of Community Service & Engagement
Vol. 1 No. 01 (2020)

The production of superoxide by mitochondria strongly depends on the mitochondrial respiratory chain. It is believed that the acetylation of cytochrome c prevents its reoxidation by mitochondrial cytochrome oxidase and direct reduction by NADH-or succinate-dependent cytochrome c reductase. It is believed that ubiquinone can be one of the major producers of superoxide because the depletion of endogenous ubiquinone resulted in the formation of diminishing hydrogen peroxide.