EFEK PROTEKSI DEKOKTA KULIT ALPUKAT PADA HEPAR TIKUS TERINDUKSI KARBON TETRAKLORIDA

Phebe Hendra (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Paramita Liong (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Brigita Wina Rosari Putri (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Angeline Syahputri Fransiskus (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Fransisca Andriani (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Asih Putriati (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)
Theresia Eviani (Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta, Indonesia)

Jurnal Farmasi Sains dan Komunitas
Vol 13, No 2 (2016)

The decoction of avocado peels was tested for their hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rat. The rats were treated with the decoction of avocado peels at doses of 363; 762, 1600 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2 mL/kg) was given on the 7th day. Different groups of rats were given water decoction of avocado peels at a dose of 363; 762, 1600 mg/kg and after 6 hours received carbon tetrachloride (2 mL/kg), respectively. The degree of protection was measured by using biochemical parameters like serum transaminase, alkaline phosphatase and albumin. From these results it suggested that the decoction of avocado peels 762, 1600 mg/kg for 6 hours has a potent hepatoprotective action upon carbon tetrachloride-induced hepatic damage in rats.