<![CDATA[Kapulaga (Amomum Cardamomum), one of Indonesia’s herbs is commonly used in comunity as a spices or remidies, and the seed is becoming the most papular part. The prior evidence showed that kapulaga had many biological properties such as antibacterial, antifungal and has been proven to reduce blood glucose and artherogenic parameter. Those previous studies promote the development of kapulaga as standardized herbal remidies. The utilization of herbal medicine especially in clinical setting must be supported by safety and effectiveness evidence, including toxicity test. Hepar was one of the target organs in the toxicity test, caused its role in the metabolism of most drugs. The aim of this study is to determine the safety profile of kapulaga seed extract through acute toxicity test in Winstar rats based on hepatic transaminase enzyme (SGOT and SGPT) level. Toxicity test was guided by the OECD 420 Fixed Dose Procedure. Preliminary test using 300 mg/kg BW dose and followed by high single dose (2000 mg/kg BW) of Kapulaga The main test was conducted by dividing the rat into control and treatment groups, 5 rats in each group. Based on preeliminary test, the treatment group was given 2000 mg/kg BW in a single dose of kapulaga seed extract. In days 14th, blood from orbita vein was taken, then SGOT and SGPT were assessed by enzymatic-photometric method. Independent sample t-test were used to analyze SGOT and SGPT’s data. The mean of SGOT in control and treatment groups were 116.92±22.35 and 98.02±16.38 (p = 0.17), whilts SGPT were 58.72±8.79 and 47.64±7.30 (p = 0.06). Both of them were not statistically different. The maximum dose of Kapulaga seed extract (2000 mg/kgBW) was not toxic due to it didn’t alter the hepatic transaminase enzyme (SGOT and SGPT) in rat. ]]>
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