Organ Damage due to Elevation of Blood Pressure on NaCl-induced

Hotimah Masdan Salim (Department of Medical Biochemistry, Faculty of Medicine, Universitas Nahdlatul Ulama, Surabaya)
Ilham Putra Alam (Faculty of Medicine, Universitas Nahdlatul Ulama, Surabaya)
Widya Dio Kharisma (Faculty of Medicine, Universitas Nahdlatul Ulama, Surabaya)

Biomolecular and Health Science Journal
Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal

Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.