Althea Medical Journal
Vol 7, No 3 (2020)

Clinical Characteristics of Rhabdomyosarcoma in Children: A 4-Year Study in a Tertiary Hospital

Lelani Reniarti (Department of Child Health Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital Bandung)
Nur Fatharani (Faculty of Medicine, Universitas Padjadjaran, Bandung)
Nur Suryawan (Department of Child Health Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital Bandung)



Article Info

Publish Date
07 Oct 2020

Abstract

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcomas (STS) in children. Even though the survival rate has increased, the mortality rates remain significantly higher in developing countries due to delay in diagnosis contributed by its diverse and clinical manifestations. This study aimed to describe the clinical characteristics of RMS patients at the Department of Child Health, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.Methods: A descriptive cross-sectional retrospective study was conducted using a total sampling method on medical records of RMS patients aged ≤ 18-year-old during a 4-year period (2015-2018). Data on patient demographics, clinical manifestations, biopsy procedure, histopathological subtype, tumor size, primary site, pre-treatment staging, and treatment were reviewed and presented.Results: Of 30 data retrieved, male (57%), aged 1 to 5-year-old (47%), and diagnosed through open biopsy (63%) comprised the majority of the patients. More than half of the patients came with advanced stage of the disease (80%) and were treated with chemotherapy (83%). Most RMS patients had a tumor located in the head and neck region (40%) with a size of >5 cm (70%) and embryonal subtypes (43%). The remaining patients experienced alveolar subtype (17%), spindle cell subtype (13%), and unknown subtype (27%) of RMS.Conclusion: Children with a tumor in the head and neck region should be suspected as rhabdomyosarcoma, as there are various clinical characteristics of RMS in children found in this study. 

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Journal Info

Abbrev

amj

Publisher

Subject

Medicine & Pharmacology

Description

Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and ...