Backgrund : Staphylococous aureus infection can cause serious and life-threatening illness if it enters the bloodstream, for example meningitis, endocarditis, and species. Staphylococcus aureus is a very serious problem because of the increased resistance of these bacteria to various types of antibiotics, due to their  inappropriate use. So we need a natural alternative therapy as an antibiotic using cucumber juice. Objectives : The study aims to determine the inhibition of cucumber juice at various concentrations on the growth of Sthapylococcus Aureus. Methods  : Test method for antibacterial inhibition using concentrations of 40%, 60%,80% and using positive control and negative control. Results :   in general cucumber juice have moderate inhibitory ability on the growth of Staphylococcus aureus bacteria, and the most effective concentration is 80%. Conclusions and suggestions : Systemic infection of Staphylococcus aureus cannot be described with the profile of this study, need another research profile that can explain it.
                        
                        
                        
                        
                            
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