This research is aimed at studying the influence of medium and large industries on poverty levels in Gresik on 2002-2016. The variables used in this study is medium and large industries, a labour of medium and large industries, gross regional domestic product (GRDP) of industrial sector and poverty rate. The method used in this study used multiple linear regression and used time-series data. The results of this study simultaneously are the variables of the amount of medium and large industries, the labour medium and large industries, and the gross regional domestic product (GRDP) of the industrial sector to poverty rate is significant. While medium and large industries to poverty rate have negative and insignificant effect with a coefficient value of -0,208905. The labour of medium and large industries to poverty rate has a positive and significant effect with a coefficient value of 0,130822, the gross regional domestic product (GRDP) of industrial to poverty rate has a negative and significant effect with a coefficient value of -0,169431.
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