Synthesis and Toxicity Test Of Zinc (II) Pyridine-2,6-Dicarboxylate Complexes

Fahimah Martak (Department of Chemistry, FMIPA, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia)
Tia Ayu Christanti (Department of Chemistry, FMIPA, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesi)

IPTEK The Journal for Technology and Science
Vol 25, No 1 (2014)

Complexes of zinc (II) with pyridine-2,6-dicarboxylic acid were synthesized from a reaction between zinc(II) chloride and pyridine-2,6-dicarboxylic acid with two different methods. The first method was carried out by reflux method, mixing a certain mole ratio of metal and ligand in the mixed solution of methanol:water (1:1) as the solvent. The second method was carried out by employing a direct reaction of metal and ligand in a 1:2 mole ratio of the same solvent as it is of the first method. The first method yielded a small clear crystal grains shaped like parallelogram with the molecular formula of [Zn(H2dipic,dipic)Zn2(10H2O)]Cl4∙5H2O (Complex I-trinuclear). The second method yielded the colorless needle-like crystals and molecular formula [Zn(H2dipic)2Zn(H2O)5]Cl4∙2H2O (Complex II-dinuclear). Both complex compounds were tested their toxicity using Brine Shrimp Lethality Test (BSLT) method and obtained LC50 values of 989.26 and 503.32 ppm, respectively.