<![CDATA[Hepatocellular damage is one of the histopathologic features of malaria infection. The presence of large amounts of hemozoin pigment in the liver is associated with hepatocellular damage. Curcuma xanthorriza Roxb / curcumin as an anti-inflammatory and natural antioxidant which has a hepatoprotector function. The purpose of these study was to determine the effect of curcuma rhizome (Curcuma xanthorrhiza Roxb) extract on hemozoin pigment in the liver tissue of BALB/C mice infected with Plasmodium berghei ANKA/ PbA. Method: using 25 groups of BALB/C mice, divided into 5 groups: negative control group; positive control group and 4 treatment groups infected with PbA with extract dose of 150 mg / KgBW, 100 mg / KgBW, and 50 mg / KgBW for four days. On the fifth day the observation of liver tissue to determine deposition of hemozoin pigments by histopathological examination. Results: Statistical analysis showed that descriptively there was a decrease in hemozoin pigment in the liver tissue of mice (150 mg / KgBW extract dose decreased the most hemozoin pigment compared to other doses), but there was no statistically significant difference between the treatment groups with positive controls (p> 0.05). Conclusions: The administration of curcuma extract (Curcuma xanthorriza Roxb) has the potential to reduce the deposition of hemozoin pigment in liver tissue in BALB/C mice infected with Plasmodium berghei ANKA although statistically it is not significant.]]>
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