REVIEW ARTICLE TERAPI OKSIGEN HIPERBARIK TERHADAP KINERJA MATRIX METALLOPROTEINASE-9 (MMP-9)

Nisa Amaliya Variansyah (Universitas Hang Tuah Surabaya)
Anisa Fathonah (Universitas Hang Tuah Surabaya)
Fakhri Muhammad (Skadron 13/Serbu Pusat Penerbangan Angkatan Darat)

Jurnal SainHealth
Vol 5, No 2 (2021): September 2021

Hyperbaric Oxygen Therapy (HBOT) is a therapy that uses 100% oxygen concentration. This is closely related to hyperoxygenation. Hyperbaric therapy is becoming second-line therapy for diseases related to cell recovery. In the medicine, MMP-9 is thought to increase the incidence of cancer metastasis. This is usually a contraindication to present HBO therapy and based on the results of our study, hyperbaric oxygen therapy can reduce the expression of MMP-9 when combined with primary therapy (radiotherapy). Besides that, HBOT can also increase the effectiveness of radiotherapy and HBOT can build up to MMP-9 levels.Keywords : Hyperbaric Oxygen Therapy, Matrix Metalloproteinase-9, Metastatic Cancer