<![CDATA[ABSTRACTBackground: The highest drug abuse cases in Pontianak in 2016 are at the age of 20-30 years (88 people). Based on the level of education, the highest are at Senior High School (89 people). The district of East Pontianak is the largest drug user area (79 people). The Senior High School “X” is a school with the highest number of students in the distict of East Pontianak.Research Method:This type of research is descriptive quantitative analytic with cross sectional approach. The population of this research is the students of class X and XI from Senior High School “X” Pontianak, West Kalimantan which amounts 594 students. The technique of this research is proportionate stratified random sampling by using Slovin formula, got 86 samples.Research Result: The knowledge of students Senior High School “X” about drug abuse 50,00% is good, the attitude of students about drug abuse 61,63% is good, the attitude of health workers 55,81% is not good, and the behavior of drug abuse prevention 67,44% is good. Multivariate test result indicate a significant influence between knowledge and drug abuse prevention behavior, the result of p value is 0,004 0,05. There is a significant influence between the attitude and drug abuse prevention behavior, the result of p value is 0,003 0,05. There is a significant influence between the attitude of healt worker and drug abuse prevention behavior, the result of p value is 0,005 0,05. The attitude variable is a dominant variable that effect (6.546) to the drug abuse prevention behavior.Conclusion: There is a significant influence between knowledge and behavior of drug abuse prevention. There is a significant influence between health worker and behavior of drug abuse prevention. Attitude is the most influence variable to the behavior of drug abuse prevention.Key Words: Knowledge, attitude, behavior, drug.]]>
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