Pengaruh Pemberian Jus Buah Pepaya (Carica papaya L.) terhadap Penurunan Kadar Malondialdehid dan Asam Urat

Janette Rindana Paranoan (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia)
Harra Ismi Farah (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia)
Adam M. Ramadhan (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia)

Proceeding of Mulawarman Pharmaceuticals Conferences
Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences

Malondialdehyde (MDA) is a biomarker of oxidative stress due to the presence of free radicals in the body. Papaya fruit contains vitamin C and ?-carotene which are useful as antioxidants. This study aims to determine the initial description of MDA levels in urine and uric acid in smoker and non-smoker respondents and to determine changes in urinary MDA and uric acid levels after administration of papaya fruit juice (Carica papaya L). The research method used was experimental with a pre-post test design. The results obtained at the initial MDA level of urine of smokers and non-smokers were an average of 2.504 nmol / mL and 1.821 nmol / mL and the results obtained after giving the juice on day 7 were 1.455 nmol / mL and 0.992 nmol / mL . Meanwhile, the initial uric acid levels of each respondent were 9.6 mg / dL and 8.4 mg / dL and the results obtained after giving the juice on day 7 were 7.8 mg / dL and 6.8 mg / dL. . So it can be concluded that the provision of papaya fruit juice can reduce the levels of MDA in urine and uric acid.