Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan

Tien Setyaningtyas (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Jenderal Soedirman, Purwokerto)
Kapti riyani (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Jenderal Soedirman, Purwokerto)
Mardiyah Kurniasih (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Jenderal Soedirman, Purwokerto)
Purwati Purwati (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Jenderal Soedirman, Purwokerto)
Siti Masruroh (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Jenderal Soedirman, Purwokerto)

Molekul: Jurnal Ilmiah Kimia
Vol 16, No 3 (2021)

Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study aimed at synthesizing tripolyphosphate crosslinked chitosan (TPP-Cs) to test the antioxidant and toxicity. Synthesizing tripolyphosphate chitosan was conducted using ionic gelation method. The antioxidant activity test was studied from DPPH radicals scavenging and the ability to inhibit linoleic acid oxidation. The toxicity test was using BSLT (Brine Shrimp Lethality Test) method and Artemia salina leach nauplii. The study showed that TPP-Cs could be synthesized from pink shrimp and showed antioxidant activity. The activity was due to amino and hydroxyl groups. The BSLT method showed that TPP-Cs had the potential to be applied for antibacterial, antivirus, or anticancer products.