Struktur Histopatologi Paru-Paru Tikus Putih yang di Berikan Ekstrak Sarang Semut dan Diinduksi Parasetamol dengan Dosis Toksik

I Made Merdana (Laboratorium Farmakologi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana Jalan PB Sudirman, Denpasar, Bali)
I Gusti Putu Tovan Mahottama (Dokter Hewan, Jl. Pendidikan 1 No. 3 Perumahan Graha Kerthi, Sidakarya, Denpasar Selatan, Bali)
I Ketut Berata (Laboratorium Patologi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana Jalan PB Sudirman, Denpasar, Bali)
Luh Made Sudimartini (Laboratorium Farmakologi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana Jalan PB Sudirman, Denpasar, Bali)

Buletin Veteriner Udayana
Vol. 14 No. 2 April 2022

Myrmecodia pendan is an epiphytic plant that attaches to large trees. Myrmecodia pendans plant contains chemical compounds such as flavonoids and tannins that are known can cure various diseases. The study aimed to determine the effect of giving myrmecodia pendans extract to the histopathological lung in white rats due to the administration of toxic doses of paracetamol. This study used 24 male white rats and divided into 4 treatment groups. The histopatological changes observed were bleeding, inflammation, congestion and necrosis. The results obtained were the administration of toxic doses of paracetamol orally causes bleeding, inflammation, congestion and necrosis in the lungs of white rats. Giving extract of myrmecodia pendans can improve lung tissue due to the administration of toxic doses of paracetamol which experience bleeding, inflammation, congestion and necrosis in the white rats.