Indonesian Journal of Cancer Chemoprevention
Vol 2, No 3 (2011)

Molecular Docking of Robustaflavone Derivatives on Pi3k Protein Target and The Correlation With Its Cytotoxic Activity on Cancer Cells

Handayani, Sri ( Research Center for Chemistry, Indonesian Institute of Sciences)
Udin, Zalinar ( Research Center for Chemistry, Indonesian Institute of Sciences)

Article Info

Publish Date
30 Jan 2014

Abstract

Robustaflavone  derivatives  have  cytotoxic  effect  on  cancer  cell.  Inhibition  of  PI3K  on cancer  cell  has  correlation  with  apoptotic  induction.  The  aim  of  this  research  is  to  observe interaction  from  robustaflavone  derivatives  on  PI3K  receptor  that  may  give  contribution  to  the cytotoxic effect of the compounds on cancer cell line. Geometric optimization of robustaflavone derivatives  structured  was  done  used  Hyperchem  7.5  software.  Arguslab  4.01  software  with GAdock  method  applied  for  the  docking  step.  The  docking  result  showed  that  robustaflavone 7,4,7-  trimethyl  ether  (RTE)  has  affinity  on  PI3K  target  receptor  which  gave  the  lowest  Gibbs free energy (∆G -10,855 kcal/mol).Key words: robustaflavone, PI3K, cancer, docking

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Journal Info
Indonesian Journal of Cancer Chemoprevention
Website

Abbrev

ijcc

Publisher

Indonesian Society for Cancer Chemoprevention

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Description

Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, ...