Tiga Senyawa Oligostilbenoid dari Kulit Batang Dipterocarpus retusus Blume (Dipterocarpaceae)

Muhtadi Muhtadi ( Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia, FMIPA - ITB)
Euis Holisotan Hakim ( Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia, FMIPA ITB)
Yana Maolana Syah ( Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia, FMIPA ITB)
Lia Dewi Juliawaty ( Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia, FMIPA ITB)
Sjamsul Arifin Achmad ( Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia, FMIPA ITB)
Ikram M. Said ( School of Chemical Sciences & Food Technology, Faculty of Science and Technology, UKM)
Jalifah Latip ( School of Chemical Sciences & Food Technology, Faculty of Science and Technology, UKM)

Jurnal Matematika & Sains
Vol 10, No 4 (2005)

Three oligostilbenoids, (-)-ε-viniferin, (-)-α-viniferin and (-)-vaticanol A, together with two derivative coumarin compounds, scopoletin and (-)-bergenin, were isolated from acetone extracts of the tree bark of Dipterocarpus retusus Blume. The chemical structure of the isolates were established based on spectroscopic data, UV, IR, 1H-NMR, 13C-NMR, and by comparison with the related compounds. (-)-ε-Viniferin, (-)-α-viniferin and (-)-vaticanol A showed cytotoxic activity against murine leukaemia P-388 cells with their IC50 values were 7,8; 17,5 and 27,0 µg/mL, respectively.