Oligomer Resveratrol dari Kulit Batang Shorea assamica Dyer (Dipterocarpaceae) dan Sitotoksitasnya

Sahidin Sahidin ( Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Haluoleo)
Euis Holisotan Hakim ( Kelompok Keilmuan Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB)
Yana Maolana Syah ( Kelompok Keilmuan Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB)
Lia Dewi Juliawaty ( Kelompok Keilmuan Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB)
Sjamsul Arifin Achmad ( Kelompok Keilmuan Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB)
Nordin Hj Lajis ( Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia)

Jurnal Matematika & Sains
Vol 12, No 3 (2007)

Four resveratrol oligomers which consist of two resveratrol trimers, i.e., vaticanol A (1) and α-viniferin (2), and two resveratrol tetramers, i.e., vaticanol B (3), and isohopeafenol (4) have been isolated from acetone extract of the stem bark of Shorea assamica Dyer. The elucidations on the structure of these four compounds were based on the spectroscopic data, including UV, IR, 1-D and 2D NMR spectra, and comparison with related data reported previously. Cytotoxicity of the isolated compounds against murine leukemia P-388 cells exhibited that vaticanol A (1), α-viniferin (2), vaticanol B (3) dan isohopeaphenol (4) had IC50 of 27.0, 17.5, 46.4, and 36.0 ppm, respectively. The results showed that cytotoxicity of resveratrol trimers were relatively higher than resveratrol tetramers.