The Aging Epigenome and The Rejuvenation Strategies

Anna Meiliana (Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363)
Nurrani Mustika Dewi (Prodia Clinical Laboratory, Jl. Kramat Raya No. 150, Jakarta, 10430, Indonesia)
Andi Wijaya (Prodia Clinical Laboratory, Jl. Supratman No 43, Bandung 40114)

The Indonesian Biomedical Journal
Vol 14, No 1 (2022)

BACKGROUND: Aging is an unavoidable part of life, defined by a gradual loss in tissue and organ function and an increasing chance of death. Current studies of aging connected the genetic and epigenetic changes to cause this process.CONTENT: When the aging-related epigenetic alterations is accumulated, it may result in irregulated gene expression, metabolic instability, stem cell senescence and exhaustion, and imbalance of tissue homeostasis, which all accelerate the aging process. Altered epigenetic gene regulatory mechanisms  such as DNA methylation,  histone modification and chromatin remodeling, and non-coding RNAs can induce aging process, thus manipulating these processes give a chance for the success of age-delaying interventions.SUMMARY: Given updated tools and technologies to investigate the epigenetic regulation affecting aging processes, new therapeutic strategies to delay this process can be developed to increase longevity and improve quality of life.KEYWORDS: aging, epigenetic, senescence, autophagy, mitochondria, metabolism, rejuvenation