This study aims to determine the relationship between pharmacological therapy of epidural analgesia in normal delivery and the stability of newborns' vital signs at X Hospital Jakarta. The study used secondary data, electronic medical records, patient registration books and used quantitative methods with a cross-sectional approach. The results showed a significant relationship between temperature with p-value = 0.000 OR 5.179 (95% CI 2.684-9.992), respiratory rate with p-value = 0.027 OR 4.377 (95% CI 1.055-18.160) with and without epidural analgesia. There is no significant relationship between the first minute APGAR scores, p-value = 0.486 using the chi-square test and fifth p-value = 1,000 and pulse p-value = 0.621 using the Fishers exact test. In conclusion, epidural analgesia is safe for both mother and baby with proper monitoring. Keywords: Epidural Analgesia, Breathing Frequency, Pulse, Normal Delivery, APGAR
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