Neutrophil-Lymphocyte Ratio(NLR), Platelet-Lymphocyte Ratio (PLR) and D-Dimer to Length of Stay in ICU of Pregnancy with COVID-19 Complicating Severe Coagulopathy

Mona Galatia Marpaung (Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University Kariadi General Hospital, Semarang, Central Java)
Rizky Syahriar Syoufana (Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University Kariadi General Hospital, Semarang, Central Java)
Radith Aulia (Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University Kariadi General Hospital, Semarang, Central Java)
Julian Dewantiningrum (Department of Obstetrics and Gynecology, Faculty of Medicine Diponegoro University Kariadi General Hospital, Semarang, Central Java)

Indonesian Journal of Obstetrics & Gynecology Science
Volume 5 Nomor 1 Maret 2022

Objective: The aim of this study was to obtain data that D-Dimer levels, Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) as a prognostic factors of length of stay in ICU. The longer length of stay in the Intensive Care Unit (ICU) as an indicator of severe coagulopathy.Methods :This study uses an analytic observational study with a cross sectional approach to analyze NLR , PLR ,and the D-Dimer levels and their relationship to length of stay in ICU of pregnant women with COVID-19 infection who were treated at RSUP Dr. Kariadi during March 2020 to October 2021. Medical records of patients with pregnancy confirmed COVID-19 who were diagnosed by PCR (polymerase chain reaction) and treated at Dr Kariadi Hospital between March 2020 and October 2021 were reviewed, p value <0.05 considered significant. Results:  The mean value of D-Dimer was 3746.6 ± 4852.33 (460-20) ug/L, NLR was 8.14 ± 6.35 (2.20-29.60), PLR was 27.66 ± 20.60 (6.80-96.66). 15 were treated in ICU with Length of stay 0.3 ± 0.46 (0-1) with the significancy was NLR p 0.008, PLR p 0.073 and D-dimer p 0.225. Conclusion : High NLR, PLR and D-dimer levels correlated with severe coagulopathy that effect the length of stay in ICU.Neutrophyl-Lymphocyte Ratio (NLR) , Platelet-Lymphocyte Ratio (PLR) dan D-dimer Terhadap Lama Rawat Inap di ICU pada Kehamilan dengan COVID-19 yang Mengalami Koagulopati Berat Abstrak Tujuan: Tujuan dari studi ini untuk menilai jumlah D-Dimer , Neutrophyl-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) sebagai factor prognostic dari lama rawat inap di ICU. Metode: Studi ini menggunakan desain analitik observasional dengan pendekatan cross sectional  untuk menganalisa NLR, PLR dan jumlah D Dimer dan hubungannya dengan lama rawat inap di ICU dari Wanita hamil dengan infeksi COVID 19 yang dirawat di RSUP Dr Kariadi selama bulan Maret 2020 hingga Oktober 2021, nilai p <0.05 dianggap signifikan. Hasil: Rerata nilai D Dimer dari subjek ialah 3746,6 ± 4852.33 (460-20) ug/L, NLR  8.14 ± 6.35 (2.20-29.60), PLR  27.66 ± 20.60 (6.80-96.66). 15 pasien dirawat di  ICU dengan lama rawat inap 0.3 ± 0.46 (0-1) dengan nilai signifikansi dari NLR p 0.008, PLR p 0.073 dan D-dimer p 0.225. Kesimpulan: NLR dan D dimer yang tinggi berhubungan dengan keparahan koagulopati yang menyebabkan lama rawat inap di ICU.Kata kunci : Lama rawat inap ICU, koagulopati, kehamilan dengan COVID 19