Media Penelitian dan Pengembangan Kesehatan
Vol 24, No 2 Jun (2014)

HITUNG ANGKA LEKOSIT SEBAGAI SALAH SATU PREDIKTOR PROGNOSIS FUNCTIONAL OUTCOME DAN LAMA PERAWATAN RUMAH SAKIT PADA STROKE ISKEMIK AKUT

Gofir, Abdul ( Departemen Neurology, Fakultas Kedokteran Universitas Gajah Mada)
Indera, Indera ( Departemen Neurology, Fakultas Kedokteran Universitas Gajah Mada)



Article Info

Publish Date
23 Oct 2014

Abstract

AbstrakLekositosis merupakan petanda klasik inflamasi sistemik. Iskemik serebral akan mencetuskan respons inflamatorik  melalui  akumulasi  granulosit  dan  akhirnya  lekosit  mononuclear  di  sekitar  daerah  infark. Dengan  demikian,  hitung  angka  lekosit  kemungkinan  dapat digunakan  sebagai  indikator  prognosis outcome klinis dan lama rawat inappada stroke iskemik akut. Tujuan studi adalah untuk mengetahui apakah hitung angka lekosit dapat memprediksi severitas prognosis outcome klinis dan lama rawat inap pada stroke iskemik akut. Dalam studi prospektif ini, didapatkan 120 subyek penelitian dengan stroke iskemik akut. Hitung angka lekosit subyek penelitian didapatkan saat awal masuk rumah sakit. Prognosis outcome klinis stroke iskemik akut dinilai menggunakan National Institute of Health Stroke Scale (NIHSS) setelah keluar dari rumah sakit. Lama rawat inap dihitung dari saat masuk sampai keluar rumah sakit. Korelasi antara hitung angka lekosit dengan NIHSS dan lama rawat inap dianalisis untuk menentukan prediktor prognosis stroke iskemik akut. Hasil studi menunjukkan pasien dengan angka lekosit yang tinggi memiliki outcome fungsional neurologis yang berat berdasarkan National Institute of Health Stroke Scale (NIHSS). Lekositosis juga meningkatkan lama masa rawat inap. Angka lekosit menunjukkan  korelasi  yang  sedang  terhadap  outcome  klinis  dan  korelasi  yang  kuat  terhadap  lama rawat inap pada stroke iskemik akut (r = 0.647 dan 0.706) dan bermakna signifikan secara statistik (p < 0.001 untuk keduanya). Kesimpulan yang didapat adalah angka lekosit saat masuk rumah sakit dapat menjadi prediktor outcome fungsional neurologis dan lama masa rawat inap pada pasien stroke iskemik akut.Kata Kunci : Stroke iskemik akut; Hitung angka lekosit; NIHSS; Lama rawat inap; PrognosisAbstractElevated leukocyte count is a classic marker of systemic inflammation. Brain ischemia elicits an inflammatory response with a rapid accumulation of granulocytes and later of mononuclear leukocytes around the infarct zone. Therefore, it is possible that blood leukocyte count might serve as prognostic indicator of functional outcome and length of stay (LOS) in acute ischemic stroke. The aim of the study is to determine whether the leukocyte count can predict prognosis of functional outcome and length of stay in acute ischemic stroke. This study is a prospective study. Leukocyte count of 120 patients with acute ischemic stroke was obtained on admission to the hospital. Prognosis of functional outcome was determined by using National Institute of Health Stroke Scale (NIHSS) after hospital discharge. Length of stay was measured from admission until hospital discharge. Correlation between leukocyte count and functional outcome (as measured by NIHSS) and LOS was analysed to establish predictor of prognosis in acute ischemic stroke. Patients with higher leukocyte count had poor functional neurological outcome based on National Institute of Health Stroke Scale (NIHSS). Higher leukocyte count also increased length of stay (LOS). Leukocyte count showed moderate correlation with clinical outcome and strong correlation with length of stay of acute ischemic stroke (r = 0.665 and 0.706 respectively) and was statistically significant (p < 0.001 for both). The conclusion is that Leukocyte count on admission could serve as a predictor of functional neurological outcome and length of stay in patients with acute ischemic stroke.Keywords : Acute ischemic stroke; leukocyte count; NIHSS; Length of stay; Prognosis

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Journal Info

Abbrev

MPK

Publisher

Subject

Decision Sciences, Operations Research & Management Public Health

Description

Media Health Research and Development ( Media of Health Research and Development ) is one of the journals published by the Agency for Health Research and Development ( National Institute of Health Research and Development ) , Ministry of Health of the Republic of Indonesia. This journal article is a ...