Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology)
Vol 22, No 2 (2021): Agustus 2021

COMPUTATION STUDY OF RADIOISOTOPES GALLIUM-68 (68Ga) PRODUCTION USING LONG-LIVED & HIGH ACTIVITY METHODS

Badra Sanditya Rattyananda (Center for Applied Nuclear Science and Technology – National Nuclear Energy Agency)
Muhamad Abdulkadir Martoprawiro (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology)
Aminatus Arifah (Master Program of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology)
Aristia Pratiwi Meliawati (Master Program of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology)
Merika Indri Widayanti (Master Program of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology)
Rasito tursinah (Center for Applied Nuclear Science and Technology – National Nuclear Energy Agency)
Yanuar Setiadi (Center for Applied Nuclear Science and Technology – National Nuclear Energy Agency)



Article Info

Publish Date
28 Mar 2022

Abstract

Radioisotopes used for gamma-ray-based diagnostics have the main problem that imaging resolution quality.Gallium-68 is a positron (β+) emitting radioisotope that has better imaging resolution than gamma-based radioisotopes. Gallium-68 (68Ga) can be produced by irradiating natural gallium or zinc-68 enriched as a target with protons in an accelerator facility. Indonesia has planned to build a cyclotron type accelerator that operates in 13 MeV proton energy and 50 µA proton beam who has initials named DECY-13. Before it was commissioned for radioisotopes production purpose that was must conduct a preliminary study to determine 68Ga optimum irradiation time and properties, one of which was the monte carlo computation method using PHITS v3.24 software. Simulations were begun by irradiating proton with natural gallium target for 25 days with 2 days cooling and zinc-68 enriched for 120 minutes with cooling 10 minutes. The results at EOB of the long-lived process using the natGa target obtained total radioactivity of 189.42 MBq (5.12 mCi). The total radioactivity result of high activity process which used 68Zn enriched as a target was 268.6 GBq (7.259 Ci). the radioactivity was compared with another accelerator, that the long-lived process was too small and uneconomical to done, but the high activity process was feasible to produce. The results of this research expected will be considered as a feasibility study for the 68Ga production process in Indonesia in the future.

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Journal Info

Abbrev

jstni

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics

Description

Focus of Publication in Indonesian Journal of Nuclear Science and Technology : Result of experiment in the field of nuclear science and technology and its applications in various fields. Acceptable topics include: Radioisotope, Radiopharmacy, Nuclear Medicine, Nuclear Radiation and its ...