This study aims to determine the climbers' understanding of AMS and the incidence of AMS that has been experienced while climbing. This research method is quantitative research with a cross-sectional study approach. The results of this study indicate the level of knowledge of 128 respondents (85.3%) in the excellent category. The incidence of AMS in most climbers experienced mild AMS among as many as 86 respondents (57.30%). In conclusion, there is no relationship between knowledge and AMS incidence in mountaineering students in Makassar City. Keywords: Acute Mountain Sickness (AMS), Climber, Knowledge
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